Rigor and Reproducibility

The theme for the 2018 SEASR Annual meeting will be rigor and reproducibility.  Biomedical researchers have an ethical responsibility to ensure the reproducibility and integrity of their work, so that precious research resources are not wasted and, most importantly, flawed or misleading results do not make their way to clinical studies where the faulty evidence could adversely affect study participants. Many factors have been suggested as contributors to irreproducible biomedical research, including poor study design, analytic instability of measurement methods, sloppy data handling, inappropriate and misleading statistical analysis methods, improper reporting or interpretation of results, and, on rare occasions, outright scientific
misconduct. These problems can occur in any type of biomedical study, whether preclinical or clinical, large or small. Specific sessions at the 2018 meeting will focus on examples of the many potential pitfalls along with suggested approaches to avoid them. The focus will mainly be on issues that arise commonly in preclinical and small clinical studies or studies performed retrospectively using stored biospecimens. Sessions in this years meeting will elaborate on aspects that are particularly problematic in research involving the use of novel measurement technologies such as “omics assays” which generate large volumes of data and require specialized expertise and computational approaches for proper data analysis and interpretation. The discussions will emphasize the importance of including in a research team all individuals with the needed expertise as early as possible in a project in order to promote a sense of engagement and facilitate good communication across disciplines. Shared credit for
scientific accomplishments should be understood as an acceptance of shared accountability for the integrity of the work.